False negative Helicobacter pylori should be reviewed in a timely manner, if the review is positive, it is necessary to follow the doctor’s instructions for quadruple therapy treatment. 1. False-negative is seen in patients who originally had H. pylori infection and recently applied antibiotics, bismuth, proton pump inhibitors and other drugs, such as metronidazole, bismuth potassium citrate, omeprazole, etc., and it is easy to have a false-negative test for H. pylori during the treatment period. In this case, the test needs to be done again after stopping the medication to determine if the infection is truly absent. If the patient is negative and asymptomatic after retesting, no treatment is needed. 2. If the test is positive, medication is needed to eradicate H. pylori. The treatment program is 1 type of proton pump inhibitor + 2 types of antibiotics + 1 type of bismuth, and the course of treatment is 10~14 days. Proton pump inhibitors commonly used omeprazole, lansoprazole, etc.; antibiotics such as clarithromycin, metronidazole, etc.; bismuth including bismuth potassium citrate. Helicobacter pylori infection can progress to chronic gastritis, peptic ulcer and so on. Daily life patients pay attention to light diet, eat more fresh vegetables and fruits, avoid spicy stimulating food. Appropriate increase in physical exercise, improve body resistance. It is recommended that patients should go to the hospital in time if they have any discomfort. After clarifying the cause of the disease, follow the doctor’s instructions to actively treat.