The prognosis of Paget’s disease, or Paget’s disease of the breast, depends on the presence of deep invasive ductal carcinoma or axillary lymph node metastases. Tumor staging has greater prognostic significance than Paget’s disease. Deep breast cancer, i.e., ductal carcinoma in situ (DCIS) and/or invasive carcinoma, is associated with Paget’s disease in 85%-88% of patients, but is usually absent of a breast mass and abnormal mammogram. In general, the 5-year survival rates are 20%-60% and 75%-100% in patients with and without a palpable mass, respectively. With a palpable mass and invasive ductal carcinoma, the 5-year cause-specific survival rate was 37%-43%, whereas it was 90%-100% in the presence of DICS alone without a mass. Patients are advised to seek prompt medical attention and treatment under medical supervision to improve their prognosis.