Simple HPV (human papillomavirus) 53 positive is not serious, if the TCT (liquid-based thin layer cell) test is abnormal, further pathology biopsy is needed for judgment. 1. Normal TCT test: HPV53 infection with normal TCT test is not serious, if the infected person has good resistance, he can enhance immunity through life conditioning to realize self-healing, without treatment, and can be rechecked regularly. For middle-aged and old people with low resistance, they need to take immunomodulating drugs (such as transfer factor) to increase immunity and help to realize the conversion. 2. Abnormal TCT test: HPV53 belongs to high-risk type, long-term infection can lead to cervical cancer and other adverse prognosis, if the TCT test is abnormal, it is necessary to further colposcopy biopsy, clear cervical lesions, if there is cervical pre-cancer, then the situation is more serious, and need to be treated early (such as cervical conization). To summarize, HPV53 infection is not serious and does not require treatment in most cases if the resistance is good. However, for those with low resistance, timely intervention is needed to avoid long-term infection that may lead to cervical cancer. Since HPV53 can lead to cervical cancer, it is important to follow the doctor’s instructions to carry out relevant examinations and treatments in a timely manner after infection.