Monkeypox is an infectious disease characterized by changes in the skin surface rash, which progresses from macules to small blisters and then from small blisters to pustules. Monkeypox was first found in monkeys in Africa, and can be transmitted both among animals and in the population, and is a zoonotic viral infectious disease. Monkeypox infection in humans can appear fever, myalgia, lymph node enlargement and other clinical manifestations, and the characteristic manifestation is the appearance of skin rash, initially maculopapular rash, gradually evolved into small blisters, and finally become pustules, which can appear in any part of the body. Monkeypox is a contagious disease that requires immediate medical attention and timely isolation for treatment.