The term “great aunt” refers to menstruation. After taking progesterone, most will have their period three to seven days after stopping the medication. Progesterone is an active progestin hormone secreted by the ovaries that protects the lining of a woman’s uterus, and during pregnancy, it also provides for the growth and development of the fetus. If a woman needs to take progesterone for treatment due to a related disease, usually it is necessary to project the appropriate dose of the drug according to the cycle of taking the drug. Usually, three to seven days after stopping the drug, the endometrium will undergo retreating bleeding and form menstruation to be discharged from the body. In addition, while taking progesterone, it may cause adverse reactions such as spotting vaginal bleeding, breast pain, insomnia and dizziness. Most of the people who use the drug can tolerate it, while a small percentage of the population cannot tolerate it, then they need to seek medical advice, adjust the dose of the drug, or suspend the drug. Progesterone is contraindicated in people who are allergic to progesterone, have a history of breast tumors, or have had a stroke. Progesterone medication must follow the doctor’s instructions, the need to maintain consistency, do not miss the dose, more than one dose, etc., the emergence of obvious symptoms of discomfort, the need for timely medical attention.