Entecavir and tenofovir disoproxil fumarate are not exactly the same due to the mechanism of action, indications, so there is no which one is better, depending on the person, choose the right drug for the patient to use. 1. Entecavir: commonly used dosage forms are tablets and capsules. It is an antiviral drug used for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase (ALT), or active lesions on liver histology. Adverse reactions include headache, fatigue, dizziness, diarrhea, abdominal pain, nausea, delayed menstruation, rash, elevated blood creatinine, hepatic discomfort, myalgia, and insomnia. It is contraindicated in persons who are hypersensitive to entecavir or any of the components of the preparation. 2. Tenofovir disoproxil fumarate: used for the treatment of HIV infection, chronic HBV infection. It is used in combination with other reverse transcriptase inhibitors in the treatment of HIV-1 infection, chronic hepatitis B. Adverse reactions include generalized weakness, diarrhea, abdominal pain, loss of appetite, nausea, vomiting, flatulence, pancreatitis, centripetal obesity, buffalo’s back, terminal emaciation, breast enlargement, Cushing’s syndrome, dizziness, headache, and dyspnea. The drug is contraindicated in patients with hypersensitivity to tenofovir, tenofovir disoproxil or any excipients in tenofovir tablets. Because the above two drugs mechanism of action, indications, contraindications and adverse reactions, etc., are not exactly the same, so the use of drugs need to be different from person to person, select the appropriate drug for the patient to use, and there is no which one is better. The application of drugs should be carried out under the guidance of a physician, do not use drugs privately, so as not to cause adverse consequences.