A cough and tickle in the throat when sleeping is clinically considered as reflux pharyngitis. Reflux pharyngitis has a history of acid reflux before, and may have a preference for smoking, sweet and sour foods, etc. Gastric acid reflux flows back to the throat through the esophagus, causing irritation to the mucous membrane of the throat, causing congestion and swelling of the mucous membrane of the throat, especially the swelling of the aryepiglottic region causing throat itching and coughing, and the excitement of the vagus nerve during sleep at night can cause reflux of gastric acid, resulting in throat itching and coughing. For treatment, diet needs to be less or no sweet and sour food, and antacid treatment such as omeprazole treatment and purgative and detoxifying drugs such as Yi Qing tablets are given. With the above treatment, the symptoms of sleeping with itchy throat and cough at night will be effectively improved until they disappear.