The normal quality of sperm in a 35-year-old man who has not had sex for a long time is mainly related to the health of the testes, epididymis, prostate and other tissues and organs. Sperm are mainly produced by the seminiferous tubules of the testes, with spermatogonia gradually dividing and developing continuously, eventually maturing and being stored in the epididymis. Normally, the maturation cycle is around 70 days. After sexual stimulation, spermatozoa mixed with prostate fluid form semen discharge. When a man does not have sex for a long period of time, the sperms automatically wither and are absorbed by the body. There is no direct correlation between having sex and sperm quality. Sperm quality is mainly related to the health of the testicles, epididymis, prostate and other tissues and organs. Abnormal sperm quality may occur if the patient has conditions such as testicular inflammation, epididymitis, seminal vesicle adenitis, or prostatitis. Conditions such as oligozoospermia, weak sperm, and azoospermia occur, affecting fertility. Therefore, it is necessary to pay attention to self-protection in daily life, reduce the stimulation to the above mentioned tissues and organs, avoid bad habits such as smoking and drinking, and stay away from sources of radiation and harmful chemicals to ensure good sperm development.