Menstruation and menopause, high altitude flight, etc. can cause toothache, odontogenic diseases, neurological diseases, etc. can also cause toothache. 1. Non-disease factors: some female patients may have toothache during menstruation and menopause, which may be related to hormone level regulation. When flying at high altitude, the pressure in the dental pulp increases, which can also cause toothache. 2. Disease factors (1) Diseases of odontogenic origin: Acute pulpitis, acute apical periodontitis, acid erosion, periodontal abscess, pericoronitis, acute purulent maxillary sinusitis and other diseases, the patient will have toothache symptoms. (2) Neurological diseases: Trigeminal neuralgia can also present with symptoms of toothache. There are many causes of toothache, and it is recommended to go to the hospital in time for consultation and timely treatment.