Down’s Screening Critical Risk It is necessary to have a non-invasive DNA test to more accurately determine if the fetus has a chromosomal abnormality disorder. A Down’s screening result of critical risk indicates that the fetus may or may not have any abnormality with Down’s syndrome, try to go to the hospital for a non-invasive DNA test within the time frame of 12-26 weeks of pregnancy. Non-invasive DNA uses a high-tech DNA sequencing method that can identify each chromosome based on the DNA sequence to rule out the presence of Trisomy 21 and Trisomy 18 in the fetus, and there is no need for further treatment if the test results are not abnormal. If the result of non-invasive DNA test is abnormal, further amniocentesis is needed. The accuracy of amniocentesis is higher than that of Down’s syndrome screening and non-invasive DNA, and if there is no abnormality in the test result, then continue the pregnancy; if there is any abnormality, we should cautiously consider whether to keep it or not. It is important to do a good job of pregnancy checkups to be able to know if there are any abnormalities in the growth and development of the fetus in the uterus.