Sacubitril valsartan is taken twice a day because the longest half-life of the drug components of this product is about 11 hours, and it needs to be given twice a day to better lower blood pressure. Sacubitril valsartan instruction manual points out that this product into the human body after the decomposition of sacubitril, LBQ657 and valsartan, the three plasma half-life of the drug is about 1.43 hours and 11.48 hours, 9.90 hours, respectively. Therefore, twice daily dosing can better maintain the antihypertensive effect. Sacubitril valsartan can be used in hypertension and chronic heart failure with low ejection fraction. It is contraindicated in people who are allergic to the drug, idiopathic or hereditary angioedema, severe hepatic impairment, and mid- to late-term pregnancy. Adverse reactions are renal function impairment, angioedema, hypotension, hyperkalemia and so on. The drug should be used rationally under the guidance of a doctor.