Due to the complexity of SLE clinical manifestations and individual differences in response to hormones, it is difficult to have a uniform dosing pattern, and the use of hormones is esoteric. The doses used are small, medium, large and shock doses. When to choose the shock dose and when to reduce to small dose must be based on the condition and vary from person to person. Generally speaking, the shock dose should be used when there is involvement of important internal organs such as heart, kidney and brain and severe anemia, leukocyte or platelet reduction. The shock dose is 1000 ml of methylprednisone added to 5% glucose solution intravenously once a day for three days, and repeated once in January if necessary, or flexibly applied by the physician according to the condition. After three days of shock, i.e. on the fourth day, the dose can be changed to oral prednisone 60 mg/day (40-60 mg/day is the high dose) and gradually reduced to prednisone 30 mg/day (medium dose) and 15 mg/day (small dose). If the disease becomes stable, the dose can usually be reduced by 5 mg per week at greater than medium doses. If you want to reduce the medication at the medium dose, reduce it by 5 mg per month. It is important to understand that even small daily doses of prednisone can still have side effects, so reducing to the lowest maintenance dose possible is a common goal for both physician and patient. 5-10 mg of prednisone every other day is perhaps the most desirable therapy, as taking hormones every other day preserves or restores hypothalamic-pituitary-adrenal axis function, significantly reduces hormonal side effects, and is indicated for long-term use. When using hormones, close attention should be paid to any adverse reactions such as infection, hypertension, diabetes, peptic ulcer, osteoporosis, aseptic osteonecrosis, etc. Under the guidance of the physician, master the principles of medication and observe closely, there is no need to worry too much about the side effects and stop the medication at will, or lose the opportunity of treatment by not using it when it should be used. Of course, this requires the physician’s rich clinical experience and the patient’s close cooperation, because sudden discontinuation or improper use of medication will not only lead to relapse or aggravation of the disease, but also increase the occurrence of side effects.