In order to protect the susceptible population and prevent the occurrence of infection, some non-specific or specific methods are often used to improve the ability of the population to resist the disease. Preventive vaccination with live (epidemic) vaccine, dead (epidemic) vaccine or toxoid to make the body produce the corresponding antibodies is called active immunity, while if the body is injected with biological agents such as antitoxin, gammaglobulin or high-value immune gammaglobulin is called passive immunity. Passive immunity causes the body’s immunity to appear rapidly, but it is maintained for 1-2 months at most. Since SLE itself has immune dysfunction, especially in the active phase of the disease there is a strong immune response, such as vaccination, foreign protein as a special antigen can cause immune response, resulting in fever, arthralgia, and even nephritis and encephalitis. Patients with SLE in remission can generally be vaccinated, including influenza vaccine and tetanus antitoxin, but they should still be used with caution for those with allergies.