On September 28, with the active cooperation of the Department of Gastroenterology, Director Zhu Xiaocheng’s team at the Gastroenterology Treatment Center successfully rescued a rare case of gastrointestinal hemorrhage. The patient has now been discharged from the hospital. The patient, a 50-year-old male, was admitted to our gastroenterology department for repeated gastrointestinal bleeding with a history of long-term heavy alcohol consumption. The patient had been hospitalized for examination and treatment in outside hospitals for several times, but the treatment effect was not satisfactory. This time, he was admitted to Director Teng Yinong’s group in the Department of Gastroenterology because of frequent bleeding and worsening symptoms with severe anemia. The site of gastrointestinal bleeding was not confirmed by CTA, DSA, gastroscopy, enteroscopy and other auxiliary examinations, and the patient still had intermittent bleeding with various medical treatment measures. Later, after consultation and discussion with Professors Fei Sujuan, Teng Yinong and Wang Ying of the Department of Gastroenterology, Prof. Zhu Xiaocheng and Deputy Chief Physician Shao Yong of the Gastroenterology Center, it was concluded that the site of gastrointestinal bleeding was probably in the small intestine and intraoperative enteroscopy must be performed to further clarify the bleeding site and escort the surgical operation. After making adequate preoperative preparations and formulating a thorough and detailed treatment plan, Zhu Xiaocheng’s team performed a dissection on the patient, which lasted for 5 hours. The operation was completed successfully and the nursing team led by nurse practitioner Du Yue’e was ready for nursing care. The patient was out of bed on the third day after surgery and has now recovered and discharged from the hospital. According to Director Zhu Xiaocheng, most gastrointestinal bleeding can be clarified by gastroscopy and colonoscopy, but there are still nearly 5% of patients who cannot be diagnosed, called unexplained gastrointestinal bleeding (OGIB). Because the lesion is mainly located in the small intestine, it is also called small intestine bleeding. At present, the most diagnostic and promising technique for small bowel bleeding is double balloon small bowel microscopy, and its diagnostic rate is about 76%-80%. Although surgical exploration is an effective method for localizing and diagnosing small bowel bleeding, it is extremely risky and has been reported to lead to 12% surgical complications and 8% surgical mortality, which undoubtedly limits the clinical application of caesarean exploration. In this case, we used intraoperative colonoscopy to confirm the site of small bowel bleeding and successfully performed intestinal resection with smooth postoperative recovery, which provided a new idea for the treatment of gastrointestinal bleeding.