The principles of resuscitation for upper gastrointestinal bleeding are: supportive therapy, fluid transfusion, blood transfusion to prevent and correct shock, and the use of appropriate hemostatic drugs. Blood transfusion is the most important part of the resuscitation process, and fresh blood rich in clotting factors should be used. Another important measure of resuscitation is to stop bleeding. Methods include pharmacological hemostasis, mechanical compression (three-chambered two-cystic tube compression) hemostasis, endoscopic vascular embolization hemostasis and surgical hemostasis. 1, drug hemostasis: cirrhosis portal hypertension leading to esophageal and gastric fundic vein bleeding, should try to reduce the portal pressure, can be taken orally or intravenous injection of posterior pituitary hormone, octreotide pressor and growth inhibitor. At the same time, use hemostatic agents, such as vitamin K, anloin, 6-aminoacetic acid, anti-fibrinolytic aromatic acid and Chinese herbal medicine, such as hyoscyamus powder and Ziziphus. 2.Mechanical hemostasis: mainly for hemostasis by compression of three-chambered two-cystic tube. This method should be used immediately if there is no hemostatic effect even with the above mentioned drugs, and surgery cannot be performed immediately. If the balloon is properly placed, the hemostatic effect can be achieved. When applying, the gastric balloon should be inflated more, usually 200-400 ml; the esophageal balloon should be inflated relatively less (80 ml), because the esophageal varices mostly originate from the fundic vein, as long as the fundic vein is compressed, the bleeding can be stopped. If the bleeding still can’t be stopped effectively, the amount of inflated esophageal bursa should be increased continuously. Some people also advocate the injection of saline plus norepinephrine 8 mg into the gastric tube to constrict the gastric mucosal vessels so as to have an effect on those who continue to bleed after balloon compression. To avoid damage to the compressed mucosa, the air should be deflated for 1-2 hours every 12 hours of compression. Compression measures to stop bleeding generally do not exceed 3 days, and those who still bleed after 3 days should consider taking other measures. 3.Endoscopic hemostasis: endoscopic sclerotherapy can be used for patients for whom conservative medical treatment is ineffective. The hemostasis rate of acute bleeding reaches 95%. For the hemostasis site of the blood vessel embolization hemostasis, if the bleeding site is not easily determined, endoscopic spraying of thrombin can be used to stop the bleeding. 4.Surgical treatment: If there is still a lot of bleeding or repeated bleeding with the above methods, surgical treatment should be considered, such as: ligation of gastric fundus and esophageal varices; transection of gastric fundus, and then gastric-gastric anastomosis; if the patient’s general condition is still stable, consideration can be given to portal vein or splenorenal vein anastomosis shunt surgery.