There are many cancers that can cause shoulder pain, which are reflected in the following aspects: 1. The more common malignant tumors in clinical practice, such as lung cancer, liver cancer, pancreatic cancer, colorectal cancer and other malignant tumors, will cause pain in the shoulder when invasion, metastasis or spread occurs, especially when bone metastasis occurs, the pain is more obvious. Usually, patients cannot be relieved by resting or using topical drugs, and pain symptoms persist, so analgesics should be applied to relieve the symptoms if necessary. 2. Another reason that can cause shoulder pain is the lesion of the shoulder itself, such as bone tumor, osteosarcoma, malignant fibrous histiocytoma, high-grade fibrosarcoma, etc.. When the mass gradually increases in size, it will compress the intercostal nerve or make the lymph nodes swell, which can cause shoulder pain; 3. Patients with lymphoma, uremia and other diseases can also cause shoulder pain. Therefore, it is recommended that patients should not ignore shoulder pain in their daily life, and should seek medical attention in time for early detection and treatment.