The effect of the quadruple pill on the stool after taking it usually disappears in about 3 to 5 days after stopping the drug, but the exact duration of the effect varies from person to person. Quadruple combination of drugs generally refers to four drugs for the treatment of Helicobacter pylori, including a proton pump inhibitor, a bismuth and two antibiotics, such as omeprazole, colloidal bismuth pectin, amoxicillin, clindamycin and so on. After taking the quadruple combination of drugs, there may be drug side effects, resulting in intestinal flora imbalance, causing increased stools, increased frequency, etc., which usually get better in about 3 to 5 days after stopping the drugs. During the period of taking Quadruple Therapy for H. pylori, it is recommended to take the medication correctly according to the doctor’s instructions, do not adjust the dose of the medication or change to other medications without authorization. If taking the quadruple pill only affects the stool and there are no other abnormal symptoms, you can continue to take the medicine. If other symptoms occur after taking the quadruple pill, you should go to the hospital as soon as possible, and cooperate with the doctor to adjust the treatment plan.