Fear of cold means fear of cold, cold, commonly found in anemia, malnutrition and other frail people, or various infections caused by fever early symptoms. Anemia or malnutrition and other weak people, due to the body’s hemoglobin less, oxygen-carrying capacity decreased, resulting in tissue and organ ischemia and hypoxia and energy metabolism disorders, the lack of heat production and the emergence of cold hands and feet, fear of cold phenomenon. In the early stage of fever, the thermogenic source acts on the body temperature center, making the body temperature adjusting point move upward, and through the skeletal muscle tremor to do work, so that the heat production increases, the heat dissipation decreases and the body temperature rises, in the stage of rising body temperature, due to the contraction of the skin pores, it will feel cool to the touch, and the human body will feel chills, chills. Chilliness due to fever is often caused by infectious factors and requires prompt medical attention.