There are several reasons why it is difficult to make a fist in the palm of your hand in the morning: 1, caused by rheumatism or rheumatoid diseases. Generally after suffering from rheumatism or rheumatoid disease, many patients will have swollen joints, pain, fist clenching difficulties, stiffness and other phenomena when they get up in the morning, this situation can be improved through light activities. After waking up by participating in certain physical exercise and activities, this phenomenon of difficulty in making a fist will be significantly improved, this patient can be in the hospital inside the blood test rheumatism factor and anti-O, can do a certain diagnosis; 2, get up in the morning to make a fist difficult, may also be carpal tunnel syndrome or elbow tunnel syndrome caused. The carpal tunnel syndrome or elbow tunnel syndrome, this disease is due to nerve compression after overexertion, this kind of situation can be done in the hospital electromyography examination to help diagnose; 3, there is also difficulty in making a fist in the morning, it may also be caused by bruising caused by hand compression at night when sleeping, this situation can be improved after light activity.