Callus on the hand is also known as clinical callus, mainly for long-term pressure and friction caused by the phenomenon of thickening of the stratum corneum. It can be removed by removing the causes, medication and other methods. 1. Remove the cause: generally speaking, callus has a certain protective effect, so there is no need for special treatment, but in daily life, pay attention to reduce friction and extrusion, wear comfortable shoes, can also play a role in alleviating the symptoms. 2. Medication: for patients with thicker lesions and pain and other uncomfortable symptoms. Calluses can be soaked in hot water to promote the thickening of the stratum corneum soften, and then use the knife to scrape off the thick calluses, while the external application of keratolytic agent drugs such as sulfur salicylic acid ointment, vitamin A ointment and other drugs for treatment. So when calluses appear on the hands, you can go to the hospital to improve the examination, under the guidance of the doctor for standardized treatment, do not self-medication.