The ingredient of Betalucel is Metoprolol, and the best match for Irbesartan is not necessarily Metoprolol, and the treatment plan should be formulated according to the patient’s condition. Irbesartan’s main effect is to antagonize angiotensin II receptors, the main indication is to treat hypertension. Metoprolol mainly inhibits beta receptors, lowering blood pressure while being able to slow down the heart rate. For patients with hypertension combined with fast heart rate, Irbesartan can be used in combination with metoprolol to lower blood pressure and slow down the heart rate at the same time. But for patients with slow heart rate, Irbesartan and Metoprolol combination is not appropriate, so the combination of the two is not necessarily the best combination, according to the characteristics of each patient to choose the combination of antihypertensive drugs program. Irbesartan’s adverse reactions include flu-like symptoms, nasal congestion, runny nose, creatinine elevation, etc. It is forbidden for patients who are allergic to the drug components, breastfeeding pregnant women, and patients with severe renal impairment. Adverse reactions of metoprolol include dizziness, hypotension, nausea, vomiting, dyspnea, etc. It is contraindicated in patients with allergy to drug components, bronchial asthma, cardiogenic shock, second and third degree atrioventricular block, severe bradycardia. Hypertensive patients should choose a combined drug regimen according to their own situation, and should use the drug under the guidance of a physician.