Estradiol reference value in early pregnancy above 700 pmol/L is normal, and the level of estradiol reference value in early pregnancy has no clinical significance. Early pregnancy is mainly based on the level of blood HCG (human chorionic gonadotropin) and progesterone to determine whether the intrauterine gestational sac is well-developed or not, and is not based on the reference value of estradiol as a standard. After 7 days of the union of sperm and egg to form a fertilized egg, HCG in the blood rises rapidly, and if the HCG value doubles on the next day’s check, it indicates that the intrauterine gestational sac is well developed, and basically excludes extrauterine pregnancy. Estradiol is secreted by the ovaries, while the embryo does not secrete estradiol after pregnancy, the level of estradiol does not determine the quality of the embryo, so checking estradiol after pregnancy has no practical significance. If the blood HCG does not double in early pregnancy, there is vaginal bleeding, abdominal pain, and there is no gestational sac echo in the uterus by ultrasound, we should be highly alert to the occurrence of ectopic pregnancy, and we need to go to the hospital in time for medical checkup. Early pregnancy if the occurrence of vaginal bleeding, abdominal pain and other abnormal manifestations, you need to go to the hospital in a timely manner.