With IVF twin pregnancy, progesterone is usually used until about 12 weeks of pregnancy, depending on the condition of the pregnant woman. Conducting IVF due to egg retrieval and other reasons may cause ovarian granulosa cells to be lost, resulting in insufficient luteal function, so progesterone needs to be taken after transplantation for luteal support. The function of the placenta can be gradually perfected around 12 weeks of pregnancy, and it can produce enough progesterone to maintain pregnancy, at this time progesterone does not need exogenous supplementation, so progesterone can be discontinued. Appropriate use of progesterone has no adverse effect on the fetus, it can reduce the excitability of uterine smooth muscle, and reduce the sensitivity of the uterus to oxytocin, inhibit contractions, so it can improve the success rate of IVF. If there is recurrent bleeding during pregnancy, the duration of progesterone use needs to be extended according to the condition of the pregnant woman. The use of progesterone during pregnancy may cause dizziness, redness and swelling at the injection site, hardness and other manifestations, but most of them are relatively mild, such as local symptoms are more obvious, pregnant women can be appropriate hot compresses to improve the discomfort, the use of medication need to be strictly in accordance with the doctor’s instructions.