What do you need to pay attention to during the taking of glucose-lowering drugs? Experts say that during the taking of hypoglycemic drugs and the following drugs together need to pay attention to the following points: 1, the insulin: will make the occurrence of asymptomatic hypoglycemia, or aggravate the degree of hypoglycemia. 2, sulfonamides: can inhibit the metabolism of oral hypoglycemic drugs in the liver, delaying excretion and prolonging the half-life. Therefore, simultaneous use may cause hypoglycemic reactions. 3.Glucocorticoids: such as prednisone, cortisone, dexamethasone, etc. These drugs can increase the synthesis of hepatic glycogen and make blood sugar rise. 4, diuretics: such as dihydrocoumaric acid, tachyphylaxis, chlorothiazide and diuretic acid, etc., can inhibit the secretion of insulin by pancreatic B cells, so that hypoglycemic drugs can not play their hypoglycemic effect, resulting in an increase in blood sugar. 5, anti-allergic drugs: diabetes mellitus with allergic diseases, glucose-lowering drugs and fenagin or chlorpromazine are used together, which can counteract the hypoglycemic effect and lead to an increase in blood sugar.