When talking to many patients about hormone supplementation in the clinic, the questions that are often asked include: Doctor, will hormone supplementation make me fat? Will it cause malignant changes? Will there be any side effects with long-term use? Will femoral head necrosis occur? Perhaps now we all have some common sense and know all the bad things about hormones, so when it comes to hormone therapy, we tend to stay away from it. However, this hormone is not another hormone. The hormones we usually talk about are glucocorticoids secreted by the adrenal glands, and the drugs used for supplementation include prednisone, hydrocortisone, dexamethasone, etc. Hormone therapy is often used in the treatment of some immune diseases, allergic diseases and dermatitis. The harmful effects of taking hormones include: obesity (characteristic centripetal obesity), decreased immunity, osteoporosis, femoral head necrosis (remember that one of the sequelae of many SARS patients was this), skin rashes, etc. With the popularity of the Internet over the years, I am afraid that we have heard about the side effects of these hormones and are afraid of being used in the treatment of diseases. Regarding the use of glucocorticoids, many of them are indications for internal medicine, so I won’t go into that. Estrogen and progesterone are hormones secreted by the ovaries. Under normal circumstances, with the presence of eggs in the ovaries, there will be follicle development, ovulation as well as corpus luteum formation every month. The estrogen secreted by the ovaries plays a very important role in maintaining female sexual characteristics, such as smooth skin, enlarged breasts, thickened uterine lining and, in addition, maintaining bone density of bones to prevent osteoporosis. After ovulation, the ovaries form the corpus luteum, which secretes another important hormone, progesterone, which, as the name suggests, is the hormone that prepares for pregnancy. The effect of progesterone in the second half of the menstrual cycle will cause the endometrium to enter the secretory phase, and the endometrium will be ready for pregnancy. In some cases where the corpus luteum is not functioning very well, prolonged menstruation or gonorrhea will easily occur, and pregnancy will be affected. In obstetrics and gynecology, the basic principle of hormone supplementation is to supplement what is lacking. Once estrogen is not secreted, ovarian function often begins to decline, which is often a sign of ovarian insufficiency or ovarian failure. If FSH is >40miu/ml, it often means that ovarian function is failing and the possibility of menstruation is small. Nowadays, a prolonged menstrual cycle with FSH >25miu/ml is called ovarian insufficiency. To sum up, whether it is ovarian failure or insufficiency, it is probably because the ovaries do not produce enough estrogen, so in order to make the body function well enough, we need to supplement estrogen. We also advocate hormone replacement after menopause. For post-menopausal women, estrogen supplementation is helpful to improve their post-menopausal status, and long-term replacement can also help reduce the occurrence of osteoporosis and heart disease. There are many female obstetricians and gynecologists who are very knowledgeable about hormone replacement and long-term replacement after menopause because they know more about hormone replacement than the general population, and the benefits of hormone replacement outweigh its risks. What are the risks of long-term hormone replacement? The main problem is that the risk of breast cancer and endometrial cancer is slightly increased. The increased risk of endometrial cancer is because you are prone to it if you only use estrogen and not progestin against estrogen, and regular hormone replacement is not a very big concern. The use of progestin is often used in obstetrics and gynecology for those states where progesterone is deficient and the ovaries are not ovulating, some because of age and declining ovarian function, some because of polycystic ovary syndrome which are diseases that lead to non-ovulation, without ovulation, the ovaries cannot form the corpus luteum, and if they cannot form the corpus luteum, they are prone to progesterone deficiency, and at this time, menstruation tends to show a prolonged menstrual cycle, and once you come At this time, the menstrual cycle tends to be prolonged, and once you have a period, you either have bleeding before or after your period, and your doctor will often prescribe progesterone treatment. At this time, your body lacks progesterone, so the progesterone given by your doctor will not cause any harm to your body. There are natural and non-natural progestogens. Generally, natural progestogens are suitable for pregnancy and are relatively expensive, while non-natural progestogens are relatively cheap and are suitable for long-term menstrual control when you do not want to get pregnant. One side effect of progestin is that it tends to cause water retention in the body, so many people experience weight gain after using progestin, especially when using it for a long period of time, but it usually gets better after stopping the medication. The purpose of this article is to dispel the concerns of many patients about gynecological hormone supplementation. This hormone is not another hormone, and there is no need to worry about the side effects of hormones as you do with glucocorticoids.