Multiple neurofibromas are an autosomal dominant disease. Treatment is based on medication, radiation therapy and surgical removal. For headaches and seizures caused by multiple neurofibromas, medications can be taken to relieve the discomfort. If pain occurs, you can follow the doctor’s prescription to take pain medication such as diclofenac sodium, ibuprofen suspension, etc., and if epilepsy occurs, you can follow the doctor’s prescription to take aokaxip, carbamazepine, etc.. For the growth of neurofibromas in the skull and the emergence of serious symptoms affecting the patient’s life, it is generally recommended to carry out surgical resection. Direct removal of the tumor can effectively improve symptoms. Radiation therapy can be used for patients who are physically unable to tolerate surgery, but it cannot shrink the tumor and has a certain risk of inducing genetic mutations, so it is not used as a routine treatment. It is recommended that people with a family history of multiple neuromas be screened regularly and seek medical attention at an early stage of the disease.