The cause of wandering pain in appendicitis is related to the anatomical location and innervation of the appendix. “Wandering pain,” i.e., metastatic right lower abdominal pain, is a characteristic manifestation of acute appendicitis. Since the appendix is a peritoneal endopositional organ and is innervated by visceral nerves, it is insensitive to painful stimuli and inaccurate in localization. Specific manifestations are early periumbilical or epigastric pain, which is visceral, and with the development of the disease, the persistent inflammation causes the somatic afferent fibers of the corresponding spinal cord segments to be stimulated, which results in the emergence of detrusor pain, and the pain is shifted to the point of the right lower abdominal Mai’s point. When the inflammation further develops and involves the mural peritoneum, somatic pain may appear, which manifests as well-localized severe right lower abdominal pain, accompanied by pressure, muscle tension and rebound pain. In severe cases, the pain may involve the whole abdomen.