Neonatal impetigo is mainly treated by strengthening nursing care and medication. 1. Strengthen nursing: neonatal impetigo is a bacterial infectious skin disease, which is contagious. It should pay attention to the personal hygiene of newborns, keep the skin clean, disinfect the clothes, towels and utensils of the affected children, and disinfect the bedding as well. It is necessary to strengthen the care of the eyes, mouth and vulva, and keep the wound dry. In addition, newborns should be given loose cotton clothing to avoid friction or irritation of the skin lesions. 2. Medication: the affected area should be cleaned before medication, if the lesion exudes less, 75% alcohol can be applied to disinfect, if the lesion area is large or exudes more, you can choose isacridine solution, boric acid solution and so on for wet compresses. You can choose antibiotic ointment topical treatment, such as mupirocin ointment, fusidic acid cream, if necessary, the systematic use of penicillin, cephalosporin antibiotics. Neonatal impetigo should be timely consultation, standardized treatment under the guidance of the doctor, to reduce the adverse effects of the disease.