Loratadine tablets should not normally be taken together with azithromycin, which increases the concentration of loratadine in the plasma. Loratadine tablets are antihistamines and azithromycin is a macrolide antibiotic. Macrolide antibiotics used with loratadine tablets will increase the concentration of loratadine in the plasma and should not normally be taken together. If they must be taken together, they need to be taken separately for a period of time, and the dosage should be adjusted appropriately under the guidance of a physician. Loratadine tablets are used to relieve the signs and symptoms of allergic rhinitis, chronic urticaria, and pruritic skin diseases. Common adverse reactions include fatigue, headache, drowsiness, dry mouth, rash, etc.; it is contraindicated for those who are allergic to it, and used with caution in pregnancy and lactation. Azithromycin can be used to treat infections caused by sensitive bacteria, such as acute bronchial inflammation, sinusitis, pneumonia and so on. Its adverse reactions include dyspepsia, gastrointestinal flatulence, headache and drowsiness. It is contraindicated for those who are allergic to it, and should be used with caution in cases of hepatic insufficiency. Loratadine tablets and azithromycin should be used under the guidance of a physician, and should not be taken on their own, so as not to cause adverse consequences.