Waking up with a full-body ache is usually caused by the following five reasons: first, a cold, whether it is a bacterial cold, a viral cold or a cold with atypical pathogens, there will be a peripheral ache caused by the invasion of viruses or bacteria into the nerve roots of the body when you wake up from a nap. Second, the first day of excessive exercise, anaerobic glycolysis release excess lactic acid, lactic acid in the skeletal muscle accumulation, will also cause a general body aches and pains upon waking up. Third, endocrine system diseases, periodic hypokalemia, will also have soreness accompanied by weakness around the body, obvious when waking up. Fourth, heat stroke and other conditions, in severe cases, if there is heat cramps, heat exhaustion and pyrexia, it will cause soreness around the body when waking up from a sleep. Fifth, rare diseases such as rhabdomyolysis syndrome can also cause peripheral pain when waking up from a nap.