Otolithiasis is not usually cured by medication, but it can improve the discomfort. To cure otolithiasis, it can be treated with manipulation and repositioning or surgery. Otolithiasis usually causes dizziness, nausea, vomiting and other symptoms. It can be treated with medications such as betahistine and promethazine. These medications can improve the discomfort and quality of life, but they are not a complete cure for otolithiasis. For recurrent otolithiasis or more pronounced symptoms, manipulation can be considered. For persistent otolithiasis, the duration of the disease is more than one year, and the effect of treatment with the above methods is not very satisfactory, causing serious impact on work and life, surgical treatment can be considered, such as vestibular nerve amputation or posterior semicircular canals occlusion surgery. During the treatment period, patients should not use medication arbitrarily, should follow the doctor’s instructions, reasonable use of medication to prevent improper use of medication caused by serious adverse reactions.