The clinical symptoms of diabetic peripheral neuropathy are diverse, and the pathological changes are mainly manifested by demyelination changes and thickening of the microvascular wall of the nerve membrane, hyaline-like degeneration, thinning of the capillary inner diameter, and even obstruction. The etiology and pathogenesis of the disease are not yet well understood. Recent studies have shown that its occurrence may be related to metabolic disorders, vascular nerve disorders and vitamin deficiencies. Among them, metabolic disorders may play an important role in the occurrence of diabetic neuropathy. Hyperglycemia leads to activation of sorbitol bypass, and the final result is accumulation of sorbitol and fructose in nerve tissue cells causing a series of secondary changes, including decreased inositol concentration in nerves, decreased cell membrane enzyme activity, accumulation of sodium in axons, slowed nerve conduction velocity, nerve swelling and final structural destruction, atrophy and disappearance of nerve axons, and lamellar or progressive demyelination. A large amount of glycosylation end products can be formed during hyperglycemia, and accumulation in the vessel wall can thicken the wall and narrow the lumen, resulting in ischemic and hypoxic damage to the nerve. Pharmacological experiments on western drug Micropôle have shown that it can promote axonal flow and axonal regeneration, promote myelin formation, and have a restorative effect on the delay of axonal transmission and reduction of neurotransmitters. Therefore, the drug can improve the clinical symptoms of peripheral neuropathy. According to Chinese medicine, diabetic peripheral neuropathy belongs to the category of “paralysis” in Chinese medicine. The main pathogenesis is qi deficiency (or yang deficiency), blood stasis, and stagnation of the arteries and veins. Qi deficiency leads to inability to transport blood, and blood stasis leads to stagnation of the blood vessels and veins, both of which can lead to numbness, pain and coldness in the limbs. The treatment is to benefit Qi and nourish Blood, invigorate Blood and open the channels.