The decrease of estradiol and progesterone may be caused by over-obesity, miscarriage with aura, embryo abortion, etc., and should be treated with medication under the guidance of a professional doctor. 1. Excessive obesity: If excessive obesity causes estradiol increase and progesterone decrease, accompanied by endocrine disorders, should be under the guidance of a professional doctor to reduce body weight, take Wu Ji Bai Feng Pills, progesterone, etc., to improve endocrine disorders, and to promote the return of estradiol and progesterone levels to normal. 2. Pre-eclampsia: If estradiol increases and progesterone decreases in the early stage of pregnancy, it may cause pre-eclampsia, and you should cooperate with your doctor to take dextroprogesterone tablets and progesterone capsules to protect the fetus. 3. Embryonic Fertilization: If embryonic fertilization causes a decrease in estradiol and progesterone, you need to cooperate with your doctor to carry out a removal operation as soon as possible. If the estradiol increase progesterone decrease, it is recommended to go to the regular hospital as soon as possible for consultation and examination, after a clear diagnosis, and then take appropriate measures to deal with.