Itchy blisters on the soles of the feet are mainly caused by the following two diseases: first, tinea pedis caused by fungal infection, which requires oral itraconazole capsules once a day, two capsules a day, or terbinafine hydrochloride tablets once a day, two capsules a day, along with topical rubbing of naftifine ketoconazole ointment, or luliconazole ointment, and topical spraying of terbinafine hydrochloride spray after the topical rubbing for supplementary treatment. Secondly, palmoplantar pustulosis, the cause of which is not clear, may be related to genetics or immune disorders, can appear on the soles of the feet in clusters of small blisters, or pustules, accompanied by a certain sense of itching, in the treatment can be topical rubbing fluticasone propionate ointment, or halometasone ointment for treatment.