Actually, it is very simple to determine whether bilirubin has entered the brain or not. First, it depends on the level of bilirubin, if the level of bilirubin is >340umol/L, it is possible that it is in the brain. Secondly, it should be combined with the symptoms of bilirubin encephalopathy, which often suggest the bottom of the reaction, suggest the decrease of attractiveness, and suggest the possibility of muscle tension. Like bilirubin encephalopathy, it usually occurs in newborn babies, and if the mental status is not good, combined with high bilirubin, it needs to be considered in this way. In addition, if the bilirubin level is too high, it needs to be analyzed and treated accordingly. If it is hemolytic, a standardized plasma exchange is needed if necessary. In addition, blue light irradiation and albumin transfusion can be performed.