Quadrivalent influenza (vaccine) is not necessary for the domestic population, but group A and group A+C influenza vaccines should be kept up to date. The vaccine is usually used to prevent epidemic cerebrospinal meningitis (ECM). Epidemic cerebrospinal meningitis is caused by a meningococcal infection and occurs most often in winter and spring. Meningitis can cause severe neurological symptoms, has a high rate of disability, and there is no specific medication for the disease once it develops, which is why the Meningitis vaccine is so necessary. There are several types of vaccines, and the quadrivalent vaccine refers to the group A+C+Y+W135 vaccine, which can provide targeted prevention of the four main groups of influenza. Group A and group C are the main groups in China, and group B, group Y and group W135 are also prevalent globally. In China, the popular vaccination is group A and group A+C influenza vaccine, which is mainly used for children aged 6 months to 18 months, and group A+C influenza vaccine is used for children over 2 years old and adults. There is no requirement for the domestic population to receive tetravalent influenza vaccine, but they should be vaccinated with group A and group A+C influenza vaccines in a timely manner. Epidemic cerebrospinal meningitis (ECM) occurs predominantly in children and is spread mainly through airborne droplets. It is important to consult a doctor for diagnosis and treatment as soon as epidemic cerebrospinal meningitis is suspected.