Tingling pain on the inner side of the calf can be caused by local lesions, lumbar intervertebral disc herniation, lower extremity vascular disease and other factors. 1. Local lesions: osteoarthritis of the knee joint, muscle ligament injury of the inner side of the ankle joint, myofasciitis of the calf and other diseases can lead to pain in the inner side of the calf. Need to reduce local activities, can follow the doctor’s instructions oral ibuprofen and other anti-inflammatory analgesic drugs, but also feasible local massage, hot compresses, improve blood circulation, relieve discomfort. 2. Lumbar disc herniation: when the lumbar disc herniation compresses the nerve root, the pain and numbness can appear in the calf and other areas of nerve compression symptoms, need to reduce the lumbar activities, feasible lumbar massage, physiotherapy, traction therapy, oral analgesic and anti-inflammatory drugs such as celecoxib and methylcobalamin and other nutritive nerve drugs as prescribed by the doctor, conservative and ineffective surgical treatment is also required. 3. Lower extremity vascular diseases: arterial thrombosis, varicose veins, arterial embolism and other lower extremity vascular diseases can cause tingling in the inner calf. Rivaroxaban, apixaban and other anticoagulant drugs can be applied under the guidance of the doctor, aspirin, clopidogrel and other antiplatelet aggregation drugs can be applied, and urokinase and other drugs can be applied to thrombolytic therapy if necessary. When the inner calf tingling also need to consider whether there is diabetic neuropathy, it is recommended to consult a doctor in time, under the guidance of specialists to actively carry out the appropriate treatment, which will help to relieve the pain and other uncomfortable symptoms as soon as possible.