HPV 16 positive can be contracted by both men and women and can be transmitted through sexual intercourse. As long as one spouse is infected and does not take precautions when having intercourse, there is a risk of transmission to the other spouse. Also, being HPV 16 positive can easily cause cervical cancer in women and penile cancer in men. So it is a relatively high-risk and harmful viral infection. When a woman develops this infection, she must be evaluated by colposcopy and, if necessary, a cervical biopsy to rule out the possibility of cervical cancer; men should also be examined and treated when they become infected. If HPV 16 infection persists for a year or more, the patient has a relatively high chance of developing cancer, and this condition must be taken seriously, and women are required to undergo cervical conization if necessary.