Fire is just a common folk name, not a medical term. Chinese medicine believes that blisters at the corners of the mouth are generally associated with fire and heat, and can be treated with either internal or external methods. 1. internal method: the corners of the mouth blistering is usually due to the phenomenon of stomach fire (stomach fire and heat evil qi exuberant) caused by the phenomenon. Can choose to take some clear heat and detoxification (clear the body heat and poisonous evil) medicine to relieve the symptoms, such as ox-huang detoxification pills, clear fire gardenia oatmeal, ox-huang stomach pills and so on. Daily diet should avoid spicy things, diet should be light. Attention to the drug allergy person prohibited. 2. external treatment method: the blister is relatively large, can use sterile needle to pick through the blister, make the pus secretion in the blister discharge, is conducive to improve the local swelling and pain symptoms, also need to apply some anti-inflammatory ointment, such as erythromycin ointment, etc., can promote the faster healing of the skin. The blisters at the corners of the mouth need to be treated under the guidance of the doctor’s diagnosis, and not blindly use their own medication, so as not to cause adverse reactions.