Vulvovaginal itching and skinning using drug treatment should first clarify the cause of the disease and then targeted intervention, mycosis vaginitis usually use clotrimazole tablets, trichomoniasis vaginitis using tinidazole, bacterial vaginosis using metronidazole drugs for intervention. Mycotic vaginitis, trichomonas vaginitis and bacterial vaginosis are common gynecological infections in clinical practice, which may lead to vulvar itching, peeling, abnormal secretions, and in severe cases, may also have a greater impact on daily life. Mycotic vaginitis is usually intervened with clotrimazole tablets, trichomonas vaginitis with tinidazole, and bacterial vaginosis with metronidazole drugs. The use of the above drugs may cause the organism to experience adverse reactions such as vomiting and headaches, and is contraindicated for those who are allergic to the components of the drug or have severe liver insufficiency. Vulvar itchy skin may also have other causes, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, to give targeted treatment or treatment, do not self-medication, so as not to produce other problems.