Long-term treatment options for GERD mainly include gastric acid suppression therapy and prokinetic therapy. 1. Inhibition of gastric acid therapy: the main methods of inhibition of gastric acid therapy include histamine H2 receptor antagonists and proton pump inhibitors, etc. The former can act on one of the links of gastric acid secretion, thus helping to relieve the patient’s symptoms. The former can act on one of the links of gastric acid secretion, thus helping to relieve the patient’s symptoms, such as famotidine, ranitidine, etc. The latter can inhibit the secretion of gastric acid, thus helping to relieve the patient’s symptoms. The latter can inhibit the secretion of gastric acid more strongly, and can work within a few days, such as rabeprazole, omeprazole and so on. 2. Promotional therapy: Promotional therapy is mainly applicable to some patients with gastric emptying disorder and impaired gastric tolerance, such as itopride and domperidone. If GERD is diagnosed, patients are advised to seek medical treatment as soon as possible to avoid delay and aggravation of the condition. The medication should be administered under medical supervision.