Breast cancer susceptibility genetic test indications 1. People who do not yet have obvious symptoms but have the following risk factors can use the test to understand the risk of breast cancer and provide them with primary prevention measures. These risk factors include: age: the incidence rate is higher between 40 and 45 years old and continues to rise after menopause, reaching a peak around 70 years old; estrogen supplementation after menopause; early age of menarche, late age of menopause, infertility and high age of first birth; family genetics. Lobular hyperplasia or atypical hyperplasia; overnutrition, obesity, high-calorie, high-fat diet; thyroid disease and endocrine disorders, decreased immune function; infertility, few births, late age of first full-term birth, early age of menarche; ionizing radiation; oral contraceptives; alcohol consumption, smoking; self-suffering ovarian disease; mental stress, infrequent exercise, etc. 2. If there are painless, solitary lumps, localized breast elevation and skin depression, flattened, retracted or sunken nipples, dermal edema and “orange peel” skin changes, the test can be used to understand the risk of breast cancer and provide an auxiliary reference for the diagnosis of the disease. 3. Due to similar symptoms, endometrial cancer should be distinguished from the following diseases: fibroadenoma. However, women after 40 years of age should not easily diagnose fibroadenoma and must exclude the possibility of malignant tumor. Cystic hyperplasia of breast, lump or local breast thickening is not clearly demarcated from surrounding breast tissue. Therefore, for patients who cannot be diagnosed or have suspicion, this test can be used to understand the risk of breast cancer in the subject and finally decide whether a biopsy should be used to confirm the diagnosis. How to interpret the test report If the test result is “–” or “-“, it can be suggested that although the test determines that you are at low risk, if you are affected by more adverse lifestyle factors, nutritional factors and environmental factors, it may increase your risk of developing the disease. Please take this into consideration and consult our medical experts. The genetic loci we have tested indicate that you are at low or no risk of developing the disease, but this does not mean that you will not develop the disease, as there is a certain incidence in the general population, so you should not neglect your health concerns. Breast cancer is one of the common malignant tumors in women, and the incidence rate in China is about 56.2 per 100,000. Enhanced surveillance: A: Monthly breast self-examinations since the age of 25 B: Professional breast check-ups at the hospital at least every 2-3 years since the age of 25-35 C: Annual mammograms since the age of 40 Drug prevention: Drug prevention can be carried out along with enhanced surveillance. Triamcinolone acetonide (tamoxifen), a selective estrogen receptor antagonist, has been shown to reduce the risk of the disease by half. Please follow your doctor’s instructions for its use. If the test result is “+” or “++” or “++++”, it may be recommended to: Intensify monitoring: A: Monthly breast self-examinations from the age of 25 years. B: Professional breast examination at least every 2-3 years since the age of 25-35 years C: Annual mammogram since the age of 40 years Pharmacologic prevention: Pharmacologic prevention can be performed along with increased monitoring. Triamcinolone, a selective estrogen receptor antagonist, has been shown to reduce the risk of the disease by half. Please follow your doctor’s instructions for specific use. Prophylactic mastectomy: This measure has been shown to reduce the risk of the disease by 90% in women with a BRCA gene variant. However, this is a very important measure and should be considered with caution and medical advice.