Strictly speaking, there is no significant difference between the preventive effect of domestic and imported vaccines after vaccination, because the listed vaccines will pass the heavy inspection of the Ministry of Health and be qualified before entering clinical use. The main difference lies in the different strains of domestic and imported vaccines and the difference in the immunization procedures or the starting age of the vaccination targets. Due to the difference in process, the indications or contraindications are also different. Moreover, the production process and raw and auxiliary materials are different because of the different production materials in each country. Therefore, both domestic and imported vaccines can play a preventive role against diseases and parents can use them with confidence.