Fundoplication is a minimally invasive surgery with low risk, but clinically there can be risks of infection, nerve damage, deep vein thrombosis and so on. 1. Infection: During the fundoplication, if the operation is not performed in strict accordance with the principle of asepsis or if the patient’s immunity is low, skin infection and abdominal infection may occur, and clinical symptoms such as fever and chills may occur. 2. Nerve injury: during the operation of the surgery, it may also lead to the injury of the saphenous nerve, which may lead to the dysfunction of the skeletal muscle and sewing machine, limb paralysis, difficulty in walking and so on. 3. Deep vein thrombosis: the local blood is inhibited during the operation and thrombus may be formed. It is recommended that patients go to a regular gastroenterology department to assess the risk of surgery before the procedure and cooperate with the preoperative preparation to minimize the complications of fundoplication intervention.