The damage of hypoglycemia to the brain includes cognitive impairment, behavioral changes, mental abnormalities, some patients may experience mania, and if the blood glucose concentration is lower, seizures and hypoglycemic coma may occur, and severe prolonged hypoglycemia can lead to brain death in diabetic patients. If hypoglycemia is detected in time, most of it can be reversed after the glucose level rises to normal. Diabetic patients who have frequent hypoglycemia must monitor their blood sugar in time, and adjust their diet and exercise program and medication program according to their blood sugar. For non-diabetic patients, hypoglycemic episodes can occur in fasting or postprandial state. Further examination of blood glucose, pancreatic function, pancreatic CT, etc. is needed to clarify the cause of hypoglycemia and to provide targeted treatment.