There is no good medicine for penile skin ulcers, the condition is different, the use of different drugs, penile skin ulcers may be caused by folliculitis, glans penis, genital herpes, syphilis, etc., you can use miconazole cream, erythromycin, acyclovir and other drugs under the guidance of a doctor for treatment. 1. Folliculitis: when the patient’s body has a decreased immune function, allergic reaction, mite parasites, scarring, etc., when the skin barrier is damaged, resulting in bacterial invasion of the skin, may trigger the penile skin ulcers, you can use antifungal drugs for treatment, commonly used drugs are miconazole cream, clotrimazole cream, econazole cream and so on. 2. circumcision: if by bacteria, fungi, viruses, and genital area trauma, drug allergic reaction and other factors caused by circumcision, the patient’s penile foreskin and penis head appear swelling and inflammation of the reaction, so that the penile skin ulcers, commonly used drugs are erythromycin and betamethasone, etc. for treatment. 3. genital herpes: the disease is mainly caused by herpes simplex virus infection of urogenital and perianal skin and mucous membranes, the patient’s genital area blisters, itching, ulcers and other symptoms, commonly used drugs are acyclovir, famciclovir, vasiclovir and so on. It is recommended that patients under the guidance of the doctor, strictly follow the medical advice to use drugs, not blindly use drugs, so as not to cause adverse effects on the body, triggering the emergence of other diseases.