The causes of white toes include physiological reasons (such as long time soaking in water leads to skin impregnation) and pathological reasons (such as eczema or tinea pedis, etc.). 1. Physiological reasons: If the foot is soaked in water for a long time, it will lead to over-hydration of the skin of the foot, making the skin appear swollen and wrinkled, and prolonged soaking in water can lead to skin impregnation, which will make the seam of the toes as well as other parts of the white phenomenon, which is commonly seen in underwater work and unprotected workers. 2. Pathologic causes: (1) Eczema: the disease is an inflammatory skin disease caused by a variety of internal and external factors, the cause of which has not yet been clarified and may be related to heredity and contact with allergens. Especially acute eczema, can appear in the local erythema, blisters, blisters rupture appear oozing, maceration, vesicles, etc. If acute eczema in the toe crevice, can appear in the toe crevice localized red rashes, whitening, or flaking phenomenon. (2) Tinea pedis: this disease is caused by fungal infection, if the toe crevice is infected by fungi, it may cause tinea pedis, especially blister tinea pedis, on the other hand, the toe crevice area is not breathable and easy to be moist, which makes the area itchy, and the blisters will lead to the localized skin impregnation and whitish phenomenon after scratching. Due to a variety of reasons can lead to whitening of the toe seam, it is recommended that the patient go to the regular hospital in time, after a clear diagnosis under the guidance of the doctor standardized treatment.