Babies may have no reaction to the 13-valent pneumonia vaccine, or may have adverse reactions such as fever, decreased appetite, easy to cry, drowsiness or decreased sleep, diarrhea, vomiting, hives, and redness, swelling and pain at the vaccination site. The 13-valent pneumonia vaccine is a vaccine used to prevent pneumonia caused by multiple Streptococcus pneumoniae infections. It is suitable for children between 6 weeks of age and 5 years of age, and belongs to the second category of vaccine, which needs to be paid for by oneself. After vaccination, the most common reactions that may occur in infants are redness, swelling and pain at the vaccination site, itching, etc. The more common adverse reactions that may occur are mild fever, easy to cry, difficulty in sleeping or drowsiness, poor appetite, etc. The less common adverse reactions are nausea, vomiting, hives and allergy, etc. Some babies may receive this vaccine after vaccination. Some babies may not have any adverse reactions after receiving the vaccine. Adverse reactions after vaccination are usually mild and can be relieved on their own within a short period of time. If the symptoms are more serious or persistently unrelieved, it is necessary to bring your baby to the doctor in time.