Surgical resection is the first battle against glioma. The first battle is crucial and is about how tough it is to manage the entire course of glioma, the patient’s quality of life and survival. Surgery is the primary treatment of choice in the management of gliomas, with all other treatments defined as adjuvant. It is not easy to finish the first battle: annihilate more of the enemy at an acceptable cost in terms of loss of our forces. That is to say, maximize tumor removal with minimal neurological damage. Let’s take a look at the cost to our side and the annihilation of the enemy respectively Cost (loss of function): since it is a surgery, it is impossible to have no damage at all, and the loss of neurological function has to be at an acceptable level, or even if there is a loss, it is for the sake of a greater gain. There are several levels of annihilation (glioma resection): Biopsy surgery: the main purpose is to clarify the nature, and biopsy surgery may be considered when 50% of the tumor volume cannot be removed by doomed surgery. It clarifies the nature and gives a scientific basis for subsequent treatment. Partial resection: at least 50%-70% or more of the tumor volume should be resected, and survival can be prolonged by surgery. Majority resection: more than 90% of the tumor volume should be removed, which can significantly prolong the survival. Total resection: which is the total resection of the tumor on imaging. It is the degree of resection recommended by current surgical guidelines for gliomas. Imaging total resection is far from adequate because imaging borders underestimate the extent of tumor invasion. Extended resection: conscious effort is made to not limit the resection to the imaging borders, but to extend the resection to the adjacent functional borders. Maximum safe resection is achieved. Super-expanded resection: for non-functional zone tumors or non-functional zone portions of functional zone tumors, the resection margins are no less than 2 cm outside the imaging boundaries, and curative resection is expected to be achieved surgically for low-grade gliomas. The higher the resection grade, the less residual tumor, the less pressure for subsequent treatment, and the more guaranteed the outcome. Resection is done with the mindset of getting rid of the evil, as much as you can, not less. Therefore, the goal of surgery should be the highest level of resection, and then downgrade as a last resort. Fighting the first battle of glioma treatment, that is, the first surgery is very important, very important, very important.