There is a difference between Metformin Extended Release and Metformin Tablets in terms of duration of action and mode of administration. Both belong to the biguanide hypoglycemic drugs, both can be used to reduce postprandial blood sugar, commonly used in the treatment of type 2 diabetes mellitus. 1. Time of action: metformin extended-release tablets have a longer time of action than metformin tablets. Metformin extended-release tablets have a longer half-life, can continue to lower blood glucose in the body, oral 1~2 times a day; metformin tablets have a short half-life, the action time in the body is also short, oral 2~3 times a day. 2. Dosage: metformin extended-release tablets can be taken at once; metformin tablets need to be taken in portions, especially in large quantities, can not be taken at once. The common adverse reactions of metformin extended-release tablets and metformin tablets are diarrhea, nausea, gastric distension, fatigue, dyspepsia and so on. It should be noted that Metformin is contraindicated in people with hypersensitivity to Metformin, heart failure, renal insufficiency, diabetic ketoacidosis, severe infections and trauma, and alcoholism. It is recommended that patients who need to use Metformin Extended-Release Tablets or Metformin Tablets go to regular hospitals, and choose the appropriate medication for standardized treatment under the guidance of the doctor.